The best bake time and temperature for Brussels sprouts is 20 minutes at 400 degrees. The result is something you might not expect from this much-maligned vegetable: a truly delicious side dish that’s also healthy and easy to make. When the Brussels sprouts are done baking, they’ll be tender while having a toasty, crispy surface. All you need to do to make roasted Brussels sprouts is to cut them in half, toss the sprouts with oil, salt, and pepper and place them on a foil-lined pan, then pop them into the oven. You can also add seasonings like garlic, balsamic vinegar, and honey: A touch of sweet flavor can provide a nice contrast for this rich and somewhat bitter vegetable.