Tilapia tastes best when you bake it in the oven. Preheat your oven to 375 degrees Fahrenheit and once the oven comes up to temp., you can put in your tilapia. The bake time for tilapia fillets is 10-12 minutes and you can tell it’s perfectly cooked through when it is white and easily flakes with a fork. If it is still opaque when you take it out of the oven, it may need a few more minutes. You can also use a thermometer to confirm that the internal temperature reaches 145 degrees Fahrenheit. Check your tilapia at the 10-minute mark to determine if it’s ready because it’s easy to overcook it which takes all the delicious juices out of it! The best tilapia recipe is one that uses simple ingredients to elevate this delicate fish.