It only takes about 10 minutes to bake salmon in a 425-degree oven. However, when you cook salmon at such a high temperature, it’s much more likely that you’ll overcook it. Our preferred baked salmon recipe calls for you to set your oven to 375 degrees and cook the salmon inside a foil pouch. Both of these strategies can help to ensure that you end up with moist, delicious salmon that’s properly cooked all the way through. If you want to be absolutely sure that your fish is done, stick a meat thermometer in it: When it registers 145 degrees, dinner is ready.