The time to bake a large chicken breast varies depending on the oven temperature you set it to:
- 350 degrees: 30 minutes
- 375 degrees: 30 minutes
- 400 degrees: 25 minutes
- 425 degrees: 20 minutes
- 450 degrees: 20 minutes
One smart trick, though, is to cut the breasts in half to make them thinner before you cook them. This way, the meat will cook more evenly, and you don’t risk drying out the outside before the inside is done cooking. Then, bake your chicken breasts at 400 degrees for 18 minutes or until a meat thermometer registers 165 degrees.
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