The right amount of time to bake salmon at 375 degrees is about 20 minutes. One of the best ways to ensure that your fish comes out fully cooked, moist, and flavorful is to bake it in a foil pouch. Our favorite baked salmon recipe calls for wrapping the salmon in foil along with rosemary, lemon, and garlic before you put it in the oven. To test the fish for doneness, you can take its temperature at the thickest part, looking for a temperature of 145 degrees. You can also test it with a fork; if the flesh flakes easily, the fish is ready.