Chicken breastIt takes 15 to 18 minutes to bake chicken breasts at 400 degrees, depending on the size and thickness of your pieces. To be certain that your baked chicken breast is done, you’ll need to take its temperature: Insert a meat thermometer into the thickest part of the biggest piece of meat and wait a few moments, then check the reading. When the thermometer reads 165 degrees, your chicken is safe to eat.

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